Compatible PGI-220 & CLI-221 Canon Ink Cartridge – 18-Pack (6 Black, 3 Photo Black, 3 Cyan, 3 Magenta, 3 Yellow)

Compatible Brand: Canon
Status: In Stock

18 Ink Cartridges

Black: 350, Color: 500

Standard Yield

6 Black

3 Photo Black

3 Cyan

3 Magenta

3 Yellow

Popular Printer Model: Pixma MP560, Pixma MP620, Pixma MX870

  • Check My Printer Compatibility
  • These are compatible standard yield ink cartridges at a fraction of traditional OEM cartridges. Get more bang for the buck.
  • We utilize smart chip technology so you can easily track ink levels.
  • 36 Month Shield Life
  • 2 Year Warranty


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About this product

Enjoy brilliant, long-lasting prints that don’t’ smudge, smear, or bleed with this 18-pack combo of black and color PGI and CLI ink cartridges. Each Black, Cyan, Magenta, and Yellow ink tank offers seamless installation on any compatible Canon printer. With an array of colors available, your photos and documents will surely come to life.

    • Package includes 6 x PGI-220 Black and 3 x CLI-221 BlackCyanMagenta, and Yellow ink cartridges.
    • Enjoy optimum page yield at the lowest cost
    • High-quality and affordable compatible Canon ink cartridge replacements for original PGI-220 / 220XL and CLI-221 / 221 XL ink cartridges
    • The combo pack gives you the best bang for your buck
    • Can work perfectly with every compatible Canon printer including: Canon Pixma iP3600, Pixma iP4600, Pixma iP4700, Pixma MP560, Pixma MP620, Pixma MP640, Pixma MP640R, Pixma MP980, Pixma MP990, MX860, and Pixma MX870.
    • Print durable, beautifully detailed photos on photo paper

The compatible Canon cartridges let you print top quality prints of 9,600 x 2,400 dpi easily and efficiently. Using our Canon ink compatible cartridge won’t void your printer’s warranty.


Save Money on everyday Printing with High-Quality Compatible Cartridges

Compatible Canon PGI-220 and CLI-221 ink cartridges from Yoyoink help you save on costs without sacrificing quality. Each Black, Cyan, Magenta, and Yellow ink cartridge produces OEM quality prints at just a fraction of the cost. Enjoy enhanced color with a broader color gamut that you’d expect from original Canon ink, but at 75% less the price!

Product Specification

Printer Brand


Black, Cyan, Magenta, Photo Black, Yellow


Multi Pack

Part Number

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Cartridge Yield Type

Page Yield

Black: 350, Color: 500

What Canon printer uses 221 ink?

All Canon printers that use CLI-221 black and color ink cartridges belong to the Pixma series. They include: Canon Pixma iP3600, iP4600, iP4700, MP540, MP560, MP620, MP620B, MP640, MP640R, MP990, MX860, MX870, PMFP1, PMFP3, SFP1 and SFP2. 


How do you refill a canon 221 ink cartridge?

Before you proceed, make sure you have these essential items on hand:

  • The CLI-221 black or color ink cartridge you want to refill
  • Refill kit (Syringe, Ink, drill, and plug)
  • Timer (cellphone or watch)
  • Chip Resetter
  • Some tape for covering the vent holes
  • Gloves and Paper towel (wear gloves throughout the refill process for ink stain protection)

Once you have all of the printer ink refill items ready, proceed with these steps:

  1. Cover the vent holes with some tape and drill a hole at the base where it says “push.” 
  2. Make sure the plug fits on the hole. If the hole is too tight, then widen it using the next drill size. 
  3. Using a syringe, draw 1 ml of ink from the bottle and then slowly drop it into the cartridge sponge
  4. Let the cartridge sit for 2 – 3 minutes to allow the sponge to absorb the ink properly.
  5. Install the orange cap into the cartridge. Try using a rubber band to keep it securely attached during the refill process.
  6. Twist the cap to pull it out from the cartridge
  7. Draw a half or full syringe volume of ink and then slowly fill it into the tank
  8. Insert the plug into the hole and then cover it with a small piece of tape
  9. Dab off any excess ink from the cartridge with a paper towel
  10. Reset the chip. Follow the product instructions on how to do it.


Recommended Cartridges for Canon CLI-221 Ink Refill:



Are Canon 221 and 226 cartridges interchangeable?

While the Canon 221 and 226 ink cartridges look the same, the two aren’t interchangeable. Both ink cartridges have distinct specs and features and also work with a different set of Canon printer models. Canon printers that use CLI-226 / 226 XL ink like the Pixma MG5220Pixma MG5320, and Pixma MX892 aren’t compatible with CLI-221 inkClick on the Check My Printer Compatibility of the CLI-226 to view each compatible printer from the Canon Pixma series.


How to Replace CLI-221 Ink Cartridges

  1. Please turn on your printer and open its Paper Output Tray.
  2. Raise the Scanning Unit. Wait for the Print Head Holder to finish moving toward the center for the proper cartridge replacement position.
  3. Remove the empty ink cartridge. Gently press the tab and then pull the ink tank out of its slot.
  4. Ready the new ink cartridge. Unpack the item and pull out the orange tape and cap.
  5. Install the new ink cartridge. Slide its front end into the Print Head at a slanting position.
  6. Repeat the same steps for each of the other colors.
  7. Slowly lower the Scanning Unit to close it back.


Note: the cartridge replacement steps are relatively the same for all Canon CLI-221 Ink compatible printers.



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